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. 2013 Apr 19;8(4):e61314. doi: 10.1371/journal.pone.0061314

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© 2013 Gu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Ribbon representation of an overall view of p24 CTD recognition by the A10F9 Fab fragment. The p24 CTD is in blue, the Fab light chain is in yellow, and the Fab heavy chain is in magenta. The p24 α-helix (α10) recognized by the Fab fragment is in red. The residues involved in protein-protein interactions are shown in stick mode. (B) Ribbon representation of an overall view of p24 CTD recognition by Fab13B5 (PDBID: 1E6J). The p24 CTD is in blue, the Fab light chain is in yellow, and the Fab heavy chain is in magenta. The short loop between α10 and α11 of p24, which is recognized by Fab, is in red. The Tyr residues that are involved in protein-protein interactions are shown in stick mode. (C) Ribbon representation of a detailed view of p24 CTD recognition by the A10F9 Fab fragment. The residues involved in protein-protein interactions are indicated and shown in stick mode. (D) EC₅₀ calculation of BMJ4 p24 and its mutants after precipitation with the A10F9 mAb. The OD_{450 nm} vs. the A10F9 ELISA concentration curves were fitted to the half point of the effective concentration (EC₅₀), and the values are shown in brackets.