Table 2. Results of association between 5 SNPs in ATP2B2 and autism and haplotype analyses in 427 trios of Han Chinese descent.

Marker	Allele	Afreq	Additive model					Dominant model
			Families	S- E(S)	Var(S)	Z	p	Families	S- E(S)	Var(S)	Z	p
rs35678	C	0.429	287	−9	94.5	−0.926	0.355	216	−4.8	48.3	−0.683	0.494
	T	0.571	287	9	94.5	0.926		162	4.2	34.8	0.720	0.471
rs241509	A	0.549	302	−1.5	102.8	−0.148	0.882	181	7.2	38.4	1.169	0.242
	C	0.451	302	1.5	102.8	0.148		230	8.7	50.7	1.229	0.219
rs3774180	C	0.551	296	−6.5	98.3	−0.656	0.512	173	−1.8	37.2	−0.287	0.774
	T	0.449	296	6.5	98.3	0.656		220	4.7	48.9	0.679	0.497
rs3774179	C	0.191	211	−19.5	61.8	−2.482	0.013	202	−18	48.3	−2.591	0.0096
	T	0.809	211	19.5	61.8	2.482		45	1.5	9.0	0.500	0.617
rs2278556	A	0.595	305	1.5	95.3	0.154	0.878	149	−5.5	32.5	−0.965	0.335
	G	0.405	305	−1.5	95.3	−0.154		232	−7.0	53.3	−0.959	0.337
Marker	Haplotype	Afreq	Families	S- E(S)	Var(S)	Z	p	Global		p permutation a	p permutation (whole marker)
								χ2	p
rs3774180–rs3774179
	C-C	0.185	198.6	−15.8	60.3	−2.037	0.042	8.95	0.030	0.042	0.040
	C-T	0.362	271.1	9.3	86.9	1.000	0.317			0.316
	T-T	0.447	286.5	9.7	96.5	0.985	0.325			0.320
rs3774179–rs2278556
	C-A	0.183	201.8	−17.0	59.4	−2.206	0.027	8.32	0.040	0.027	0.035
	T-A	0.410	279.1	20.5	91.5	2.143	0.032			0.032
	T-G	0.400	294.5	−1	92.8	−0.104	0.917			0.905
rs3774180–rs3774179–rs2278556
	C-C-A	0.182	197.2	−16.1	58.2	−2.117	0.034	9.14	0.104	0.033	0.202b
	C-T-A	0.337	246.1	13.1	80.6	1.464	0.143			0.149
	T-T-G	0.371	260.4	3.6	88.3	0.375	0.708			0.686
	T-T-A	0.074	102.8	6.1	28.0	1.155	0.248			0.249

Afreq, allele frequency; Families, number of informative families; S, test statistics for the observed number of transmitted alleles; E(S), expected value of S under the null hypothesis (i.e., no linkage and no association).

^aThe number of permutationS is 10,000;

^bwhole marker permutation test using minimal p (when only one haplotype was significant).