Figure 5. Structural malleability of the binding pocket within the defensin-sensitive HAdV chimera (Ad5.F35).

(A) Comparison of three different HD5 dimer orientations each with respect to one fiber subunit containing the closest 18-EDES-21 sequence (spheres). (B) Comparison of penton base RGD-containing loop interactions with the same three HD5 dimers. The penton base loops are shown without the rest of the penton base. The models in panels A and B are all based on final MDFF coordinates from one vertex with a trimeric fiber and a pentameric penton base. The five penton base loops are shown in purple, cyan, blue, gold, and gray and the rest of the coloring scheme is as in Figure 2.