Table 2. Clinicopathologic features by HER2 status.
Characteristics | Categories | HER2+ | HER2− | P value |
Median age at diagnosis, years (range) | - | 43.6 (17.6–74.9) | 49.4 (15.8–82.1) | 0.094 |
Ethnic group | Chinese (n = 80) | 18 (23%) | 62 (78%) | 0.052 |
Malays (n = 16) | 9 (56%) | 7 (44%) | ||
Indians (n = 6) | 1 (17%) | 5 (83%) | ||
Others (n = 11) | 3 (27%) | 8 (73%) | ||
Smoking history | Non-smoker (n = 29) | 9 (31%) | 20 (69%) | 0.720 |
Ever-smoker (n = 14) | 3 (21%) | 11 (79%) | ||
Family history of cancer | Negative (n = 39) | 12 (31%) | 27 (69%) | 0.728 |
Positive (n = 11) | 4 (36%) | 7 (64%) | ||
Presence of comorbidities | No (n = 40) | 14 (35%) | 26 (65%) | 0.267 |
Yes (n = 68) | 17 (25%) | 51 (75%) | ||
Stage at diagnosis | I (n = 88) | 29 (33%) | 59 (67%) | 0.285 |
II (n = 5) | 0 (-) | 5 (100%) | ||
III (n = 11) | 2 (18%) | 9 (82%) | ||
IV (n = 3) | 0 (-) | 3 (100%) | ||
Tumour differentiation/grade | well (n = 64) | 19 (30%) | 45 (70%) | 0.717 |
moderate (n = 28) | 10 (36%) | 18 (64%) | ||
poor (n = 9) | 2 (22%) | 7 (78%) | ||
Tumour type | Mixed borderline (n = 45) | 17 (38%) | 28 (62%) | 0.063 |
Non-borderline (n = 65) | 14 (22%) | 51 (78%) | ||
Ovarian surface involvement | No (n = 66) | 23 (35%) | 43 (65%) | 0.075 |
Yes (n = 38) | 7 (18%) | 31 (82%) | ||
Lymphovascular invasion | No (n = 100) | 29 (29%) | 71 (71%) | 0.186 |
Yes (n = 7) | 0 (-) | 7 (100%) | ||
Median CA125, U/mL (range) | - | 37.2 (6.1–415.7) | 102.5 (3.0–8812.5) | 0.024 |
Received OGD | No (n = 93) | 29 (31%) | 64 (69%) | 0.148 |
Yes (n = 16) | 2 (13%) | 14 (88%) | ||
Received colonoscopy | No (n = 90) | 29 (32%) | 61 (68%) | 0.057 |
Yes (n = 19) | 2 (11%) | 17 (89%) | ||
Received appendectomy | No (n = 51) | 15 (29%) | 36 (71%) | 0.833 |
Yes (n = 58) | 16 (28%) | 42 (72%) | ||
Received omentectomy | No (n = 7) | 3 (43%) | 4 (57%) | 0.400 |
Yes (n = 103) | 28 (27%) | 75 (73%) | ||
Received chemotherapy | No (n = 57) | 18 (32%) | 39 (68%) | 0.419 |
Yes (n = 49) | 12 (24%) | 37 (76%) | ||
Received adjuvant chemotherapy | No (n = 69) | 19 (28%) | 50 (72%) | 0.745 |
Yes (n = 36) | 11 (31%) | 25 (69%) |
Abbreviation: OGD, oesophagogastroduodenoscopy.