Table 2. Sample characteristics and task performance group × diagnosis.
| Group; mean (SD) | ||||
| PCLO+ | PCLO− | |||
| MDD (N = 64) | HC (N = 18) | MDD (N = 25) | HC (N = 11) | |
| Sample characteristics | ||||
| Gender (%female) | 65.6% (n = 42) | 50.0% (n = 9) | 60% (n = 15) | 63.6% (n = 7) |
| Age (years) | 35.9 (9.57) | 43.2 (10.05) | 39.0 (11.38) | 40.0 (9.12) |
| Education (years) | 12.4 (3.24) | 14.7 (2.78) | 11.3 (2.85) | 13.6 (2.16) |
| Scancenter (% A, L, G) | 23.4, 46.9, 29.7 | 38.9, 33.3, 27.8 | 24, 36, 40 | 54.5, 36.4, 9.1 |
| IDS (score) | 24.3 (10.03) | 3.9 (3.26) | 22.1 (13.29) | 3.7 (3.43) |
| MADRS (score) | 16.8 (9.12) | 1.5 (2.18) | 14.4 (9.82) | .27 (.65) |
| Duration SSRI use (months) | 14.5 (19.76) | N/A | 32.0 (46.59) | N/A |
| SSRI use (no/yes) | 43/21 | 18/0 | 18/7 | 11/0 |
| Memory performance (p) | ||||
| pCREC.neg | .693 (.143) | .658 (.127) | .700 (.118) | .652 (.170) |
| pCREC.pos | .724 (.129) | .700 (.145) | .728 (.143) | .764 (.103) |
| pCREC.neu | .702 (.163) | .656 (.114) | .717 (.175) | .621 (.219) |
| pFA.all | .123 (.084) | .132 (.067) | .129 (.078) | .099 (.079) |
| pCREJ.neg | .658 (.136) | .668 (.143) | .655 (.146) | .718 (.161) |
| pCREJ.pos | .696 (.165) | .701 (.212) | .713 (.165) | .739 (.205) |
| pCREJ.neu | .807 (.136) | .846 (.106) | .800 (.142) | .884 (.083) |
| Response time (sec) | ||||
| rt SCR.neg | 1.28 (.32) | 1.32 (.57) | 1.26 (.26) | 1.24 (.37) |
| rt SCR.pos | 1.53 (.39) | 1.35 (.31) | 1.43 (.36) | 1.45 (.26) |
| rt SCR.neu | 1.59 (.39) | 1.47 (.45) | 1.52 (.32) | 1.54 (.31) |
| rt CREJ.neg | 1.51 (.32) | 1.48 (.35) | 1.44 (.42) | 1.50 (.35) |
| rt CREJ.pos | 1.56 (.34) | 1.49 (.34) | 1.50 (.37) | 1.50 (.33) |
| rt CREJ.neu | 1.41 (.31) | 1.40 (.30) | 1.37 (.37) | 1.37 (.24) |
| rt CREC.neg | 1.26 (.21) | 1.33 (.30) | 1.23 (.30) | 1.29 (.25) |
| rt CREC.pos | 1.36 (.27) | 1.42 (.31) | 1.31 (.29) | 1.30 (.24) |
| rt CREC.neu | 1.31 (.25) | 1.43 (.30) | 1.31 (.31) | 1.40 (.35) |
Sample characteristics and task performance of the total sample, divided into genotype × diagnosis. SD: standard deviation; n:number of participants; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carries; A: Amsterdam; L: Leiden; G:Groningen; MDD: major depressive disorder; HC: healthy controls; IDS: Inventory of Depressive Symptomatology; MADRS: Montgomery-Åsberg Depression Rating Scale; SSRI: Selective Serotonin Reuptake Inhibitors; p: proportion correct answers; neg: negative (words); pos: positive (words); neu: neutral (words); sec: seconds; rt: response time.
Mean proportion correct and response times for encoding (subsequent hits) and recognition (hits, false alarms, correct rejection) indices. Correct RECognition (CREC): correct recognition of a previously encoded word; False Alarm (FA): incorrect indication of a newly presented word as a previously encoded word; Correct REJection (CREJ): correct recognition of a newly presented word as a new word; Subsequent Correct Recognition (SCR): consists of a word, presented during the encoding phase, that is correctly recognized during the subsequent recognition phase.