Table 3.
Topical delivery systems based on synthetic polymeric nanoparticles.
| Synthetic polymers | Encapsulated drug/model compounds | Target treatment or effect | Particle size | Ref. |
|---|---|---|---|---|
| Biodegradable | ||||
| PLGA | Hinokitol, 6-benzyaminopurin | Hair growth | 182–210 nm | 51 |
| PLGA | indomethacin | Analgesic for transdermal delivery | 100 nm | 52 |
| PLGA-chitosan | spantide II and ketoprofen | Anti-inflammatory | 169 nm | 53 |
| Poly(ε-caprolactone) | Octyl methoxycinnamate | Sunscreen effect | 255–427 nm | 54 |
| Poly(ε-caprolactone)-block-PEG | minoxidil | Anti-hairloss | 40 &130 nm | 55 |
| Non-biodegradable | ||||
| Polystyrene | Nile red | Hydrophobic dye (to study release mechanism) | 28–31 nm | 7 |
| Poly(methyl methacrylate) | Nile red | Hydrophobic dye (to study release mechanism) | 68–100 nm | 56 |
| Polyacrylate | N-thiolated β-lactam | Antibiotic for wound healing | 40 nm | 57 |