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. 2012 Jun 4;32(16):2048–2057. doi: 10.1038/onc.2012.224

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Activation of WNT signalling in the stomach correlates with the phenotype observed in FAP patients with intestinal-type adenomas. (a) Relative expression (qRT–PCR levels) of WNT target genes Achaete scute-like 2 (Ascl2), Cyclin D1 (Ccnd1), Leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5), Naked cuticle homologue 1 (Nkd1) and Axin2. mRNA levels were measured in whole stomach tissue from AhCreER⁺ GSK3 alpha^fl/fl beta^fl/fl (experimental) compared with AhCreER⁺ GSK3 alpha^fl/fl beta^fl/+ (control) mice at day 6 post-induction. P<0.001 apart from Nkd1 P<0.097. (b) IHC staining for β-catenin and Sox9 in gastric lesions from FAP patients. Left two panels, intestinal-type adenoma; right two panels, intestinal-type metaplasia. Scale bar, 10 μm.