Figure 12.

Venn diagram of genes commonly up- and down-regulated in the telomerase deficient mutant tlc1Δ and in the DNA replication mutant dna2-1. Genes (52.15%) differentially expressed by at least twofold in senescent tlc1Δ (Nautiyal et al., 2002) and 21.89% of the genes that differ by at least twofold in the old dna2-1 cells are the same (A). Genes (57.57%) up-regulated in the tlc1Δ (Nautiyal et al., 2002) mutant are the same as 27.95% of the genes up-regulated in the old dna2-1 cells (B). Genes (34.72%) down-regulated in the tlc1Δ (Nautiyal et al., 2002) mutant are the same as 11.43% of the genes down-regulated in the old dna2-1 cells (C).