Figure 7.

Up-regulation of genes in wild-type and dna2-1, suggesting an increase in expression of genes involved in gluconeogenesis and energy storage during aging. Genes listed, except TCA cycle genes, are those that also change in old wild type as reported by Lin et al. (2001). (Results are presented as the ratio of old (O) vs. young (Y) cells and represent the average values from duplicate hybridizations). The competitive hybridizations of young cells vs. young cells for each strain allowed us to conclude that any gene showing a difference in expression level of at least twofold in the experiments comparing young and old cells could be considered significant with a 94-95% confidence level. Gene annotations are from the YPD database (https://www.incyte.com/proteome/mainmenu.jsp). (A) Genes involved in gluconeogenesis and energy storage. (B) Venn diagram of overlap between our data and the ESR (Gasch and Werner-Washburne, 2002). (C) Genes involved in oxidative phosphorylation and TCA cycle genes.