Kinetic scheme for the pseudo-substrate inhibition of inhibitors in the presence of substrate. E, enzyme (CEase); S, substrate (PNPB); ES, acylenzyme intermediate; I, inhibitors 1–17; EI, enzyme-inhibitor tetrahedral intermediate; EI′, carbamyl enzyme intermediate; P, the product from substrate reaction (4-nitrophenol); P′, the product from pseudo substrate reaction (alcohols); Q, the second product (carbamic acids).