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. 2012 Jul 18;21(9):1344–1357. doi: 10.1002/pro.2121

Figure 1.

Figure 1

Kinetic scheme for the pseudo-substrate inhibition of inhibitors in the presence of substrate. E, enzyme (CEase); S, substrate (PNPB); ES, acylenzyme intermediate; I, inhibitors 1–17; EI, enzyme-inhibitor tetrahedral intermediate; EI′, carbamyl enzyme intermediate; P, the product from substrate reaction (4-nitrophenol); P′, the product from pseudo substrate reaction (alcohols); Q, the second product (carbamic acids).