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Linear correlations of the (A) pKi, (B) log k2, and (C) log ki values with the substituent constant (σ*) of 1,2,3-tri-N-substituted carbamylglycerols (13–17) for the pseudo-substrate inhibition of CEase. In (A), pKi = 6.1 ± 0.1 – (2.4 ± 0.5)σ* and R = 0.944. In (B), log k2 = 3.75 ± 0.03 + (0.57 ± 0.09)σ* and R = 0.974. In (C), log ki = 2.39 ± 0.04 – (1.8 ± 0.1)σ* and R = 0.929. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
