Table I.

Pseudo-Substrate Inhibition of CEase by 1,3,5-Tri-N-Alkylcarbamyl-Phloroglucinols (1–12)

Inhibitors	k2 (10−3 s−1)	Ki (nM)	ki (103 M−1 s−1)a
1	2.2 ± 0.1b	10 ± 2	220 ± 40
2	3.4 ± 0.3	25 ± 6	140 ± 30
3	2.27 ± 0.07	14 ± 2	160 ± 20
4	2.19 ± 0.02	11 ± 3	200 ± 60
5	1.8 ± 0.1	20 ± 4	90 ± 20
6	1.46 ± 0.06	22 ± 5	70 ± 20
7	1.39 ± 0.05	10 ± 2	140 ± 30
8	1.49 ± 0.07	12 ± 2	120 ± 20
9	1.00 ± 0.02	20 ± 4	50 ± 10
10	1.01 ± 0.06	23 ± 7	40 ± 10
11	1.11 ± 0.05	9 ± 2	120 ± 30
12	0.89 ± 0.02	12 ± 2	70 ± 10

^aThe k_i values were calculated from k₂/K_i and uncertainty in k_i values = {(uncertainty of k₂)² + (uncertainty of K_i)²}^1/2.

^bData followed by ± signs were standard deviations obtained from least-squares curve fittings with n (number of separate experiments) > 9.