Table II.

Pseudo-Substrate Inhibition of CEase by 1,3,5-Tri-N-Substituted Carbamylglycerols (13–17)

Inhibitors	σ*	k2 (10−4 s−1)	Ki (μM)	ki (M−1 s−1)a
13	−0.13	1.4 ± 0.1b	0.14 ± 0.01	1000 ± 100
14	−0.15	1.5 ± 0.1	0.72 ± 0.04	210 ± 20
15	−0.13	1.4 ± 0.1	0.39 ± 0.01	360 ± 20
16	0.22	2.8 ± 0.2	1.90 ± 0.06	150 ± 10
17	0.6	3.7 ± 0.2	22 ± 1	17 ± 1

^aThe k_i values were calculated from k₂/K_i and uncertainty in k_i values = {(uncertainty of k₂)² + (uncertainty of K_i)²}^1/2.

^bData followed by ± signs were standard deviations obtained from least-squares curve fittings with n (number of separate experiments) > 9.