Figure 6.

(A) Concentration–response curves to PGE₂ in GPT following culture for 4 days in the absence (Control) or presence of indomethacin (INDO; 3 μM), ibuprofen (IBU; 3 μM), FR-122047 (FR; 3 μM) or lumiracoxib (LUMI; 3 μM). (B) Concentration–response curves to PGE₂ in cultured guinea pig tracheal segments in the absence or presence of INDO (3 μM) and pre-contracted with 0.3 μM CCh. (C) Concentration–response curves to histamine in cultured guinea pig tracheal segments in the absence or presence of INDO (3 μM). (D) PGE₂ immunoreactivity measured in culture media from tracheal segments cultured for up to 96 h (n = 4–17).