Table 2.
Concentration-dependent inhibition of hUII-induced contraction of rat isolated aorta by urocontrin A
| Urocontrin A (nM) | hUII Emax (% KCl) | hUII pEC50 | n |
|---|---|---|---|
| Vehicle | 120 ± 8 | 8.89 ± 0.23 | 10 |
| 1 | 89 ± 5* | 8.63 ± 0.15 | 5 |
| 10 | 61 ± 6* | 8.94 ± 0.35 | 6 |
| 100 | 45 ± 4** | 8.59 ± 0.34 | 5 |
| 1 000 | 28 ± 3** | 8.41 ± 0.47 | 7 |
| 10 000 | – | – | 3 |
All values are expressed as mean ± SEM. Statistical comparisons for both pEC50 and Emax values were performed using anova analysis with a Dunnett's post-test where
*
P < 0.05 and
**
P < 0.01 versus vehicle control values.