Table 3.
Concentration-dependent inhibition of hUII-induced contraction of cynomolgus monkey isolated aorta by urocontrin A
| Urocontrin A (μM) | hUII Emax (% KCl) | hUII pEC50 | n |
|---|---|---|---|
| Vehicle | 249 ± 24 | 7.50 ± 0.22 | 7 |
| 1 | 134 ± 14** | 7.57 ± 0.25 | 7 |
All values are expressed as mean ± SEM. Statistical comparisons for both pEC50 and Emax values were performed using unpaired Student's t-test where
P < 0.01 versus vehicle control values.