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. 2013 Jan 24;168(4):850–862. doi: 10.1111/j.1476-5381.2012.02214.x

Figure 1.

Figure 1

Effect of PAL-353, amphetamine, phenmetrazine, methamphetamine and PAL-314 on ICSS. Left panels (A, C, E, G, I) show drug effects on full ICSS frequency–rate curves. Abscissae: Frequency of electrical brain stimulation in Log Hz. Ordinates: Percent maximum control reinforcement rate (%MCR). Drug name and doses are indicated in legends. Filled points represent frequencies at which reinforcement rates were statistically different from vehicle rates as determined by a two-way anova followed by a Holm–Sidak post hoc test, P < 0.05. Right panels (B, D, F, H, J) show summary ICSS data expressed as percent pre-drug baseline number of reinforcers delivered across all frequencies of brain stimulation. Abscissae: drug dose in mg kg−1. Ordinates: Percent pre-drug baseline number of reinforcers. The drug and pretreatment time are shown for each panel. Upward/downward arrows indicate significant drug-induced increase/decrease in ICSS relative to vehicle for at least one brain stimulation frequency as determined by analysis of full frequency–rate curves. All data show mean ± SEM for five to seven rats (except for 3.2 mg kg−1 PAL-353, n = 4). Statistical results for data in left panels are as follows: (A) PAL-353 0.1–1.0 mg kg−1 (n = 7): significant main effect of frequency [F(9,54) = 88.6, P < 0.001], dose [F(3,18) = 38.8, P < 0.001] and significant interaction [F(27,162) = 7.9, P = < 0.001]. PAL-353 3.2 mg kg−1 (n = 4): significant main effect of frequency [F(9,27) = 17.1, P < 0.001], dose [F(1,3) = 12.0, P = 0.04] and significant interaction [F(9,27) = 18.8, P < 0.001]. (C) Amphetamine (n = 6): significant main effect of frequency [F(9,45) = 144.2, P < 0.001], dose [F(4,20) = 55.4, P < 0.001] and significant interaction [F(36,180) = 10.5, P = < 0.001]. (E) Phenmetrazine (n = 5): significant main effect of frequency [F(9,36) = 22.8, P < 0.001], dose [F(4,16) = 4.9, P < 0.009] and significant interaction [F(36,144) = 3.8, P = < 0.001]. (G) Effect of methamphetamine (n = 5): significant main effect of frequency [F(9,36) = 56.2, P < 0.001], dose [F(4,16) = 40.4, P < 0.001] and significant interaction [F(36,144) = 6.6, P = < 0.001]. (I) PAL-314 (n = 6): significant main effect of frequency [F(9,45) = 67.9, P < 0.001], dose [F(4,20) = 6.0, P = 0.003] and significant interaction [F(36,180) = 11.8, P = < 0.001].