Figure 5.

Effects of etanercept (ETA) and aminoguanidine (AG) on PG production. Pregnant rats (gd 15) were injected with LPS alone (50 pg g⁻¹) (shown as control) or with 0.7 ng Stx2 and 50 pg LPS g⁻¹ (shown as Stx2) and killed 12 h post-injection. Some animals were injected with etanercept (i.p., 100 μg g⁻¹) 6 h before toxin treatment. Others were treated with a combination of aminoguanidine and etanercept according the protocol described before for each one. PGE₂ and PGF_2α levels were evaluated in placenta (A) and decidua (B) by RIA. Data corresponding to at least two separate experiments are shown. Values are expressed as the mean ± SEM (n = 18). ^aP < 0.05 versus control, ^bP < 0.01 versus control, ^cP < 0.001 versus control, ^dP <0.001 versus etanercept control, etanercept + Stx2 and aminoguanidine + etanercept + Stx2.