Figure 1.

Effect of MDMA (A, E), mephedrone (B, F), cathinone (C, G) and methcathinone (D, H) on rectal (A–D) and tail (E–H) temperature in individually housed male Lister hooded rats (n = 5–6 per group). Compounds (4 or 10 mg kg⁻¹ HCl salt) or saline vehicle (1 mL kg⁻¹) were injected i.p. at 0 min and temperature assessed at 20 min intervals for the next 2 h. Data are expressed as change in temperature (°C, mean ± SEM) from the baseline reading taken at the time of injection. *P < 0.05; **P < 0.01; ***P < 0.001 versus vehicle control (two-way repeated measures anova with Bonferroni's post hoc test). Where results of multiple experiments are shown on the same graph, vehicle data have been pooled for clarity of presentation (P > 0.05 between studies; two-way repeated measures anova). However, all statistical comparisons shown relate to the original control for each experiment (n = 5–6), not the pooled values.