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Effects of 4DmiR and/or rolipram on antidepressant-like behaviour in mice. Rolipram (1.25 mg·kg−1) administration and/or long-form PDE4D knock-down in the prefrontal cortices significantly decreased immobility in the TST (A) and FST (B). Values shown are means ± SEM; n = 12–14; *P < 0.05, **P < 0.01 versus the control (NC + Veh).
