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. 2013 Jan 24;168(4):1015–1029. doi: 10.1111/bph.12005

Table 2.

Summary of the effects of TRPV1 antagonists on CGRP release elicited by maximally effective concentrations of capsaicin or PDBu

Compound Inhibition of 300nM capsaicin response n Inhibition of 1 μM PDBu response n Reference
pIC50 ± SEM (M) Inhibition (%) pIC50 ± SEM (M) Inhibition (%)
BCTC 8.46 ± 0.09 102 ± 6 3 8.93 ± 0.05** 98 ± 4 3 (Valenzano et al., 2003)
AMG-517 7.33 ± 0.02 106 ± 1 3 7.92 ± 0.05** 94 ± 2 3–4 (Gavva et al., 2007)
Neurogen 8.02 ± 0.07 100 ± 4 2 8.52 ± 0.1**4 101 ± 14 3–6 (Zheng et al., 2006)
A425619 7.12 + 0.08 92 ± 4 3 6.63 ± 0.08* 90 ± 4 3–7 (El-Kouhen et al., 2005)
A784168 6.98 ± 0.04 104 ± 3 3 6.80 ± 0.08** 95 ± 3 3–7 (Cui et al., 2006)
AMG 49a 6.78 ± 0.08 102 ± 4 3 6.55 ± 0.08* 97 ± 3 3–6 (Doherty et al., 2005)
SB705498 5.97 + 0.12 102 ± 9 3 5.46 ± 0.16 116 ± 12 3–6 (Gunthorpe et al., 2007)
JNJ17203212 6.59 ± 0.09 98 ± 6 3 6.75 ± 0.08 98 ± 18 3 (Swanson et al., 2005)
AMG-9810 5.89 ± 0.09 88 ± 5 3 6.81 ± 0.04* 84 ± 1 3 (Gavva et al., 2010)
**

P < 0.01,

*

P < 0.05.