Table 2.
Compound | Inhibition of 300nM capsaicin response | n | Inhibition of 1 μM PDBu response | n | Reference | ||
---|---|---|---|---|---|---|---|
pIC50 ± SEM (M) | Inhibition (%) | pIC50 ± SEM (M) | Inhibition (%) | ||||
BCTC | 8.46 ± 0.09 | 102 ± 6 | 3 | 8.93 ± 0.05** | 98 ± 4 | 3 | (Valenzano et al., 2003) |
AMG-517 | 7.33 ± 0.02 | 106 ± 1 | 3 | 7.92 ± 0.05** | 94 ± 2 | 3–4 | (Gavva et al., 2007) |
Neurogen | 8.02 ± 0.07 | 100 ± 4 | 2 | 8.52 ± 0.1**4 | 101 ± 14 | 3–6 | (Zheng et al., 2006) |
A425619 | 7.12 + 0.08 | 92 ± 4 | 3 | 6.63 ± 0.08* | 90 ± 4 | 3–7 | (El-Kouhen et al., 2005) |
A784168 | 6.98 ± 0.04 | 104 ± 3 | 3 | 6.80 ± 0.08** | 95 ± 3 | 3–7 | (Cui et al., 2006) |
AMG 49a | 6.78 ± 0.08 | 102 ± 4 | 3 | 6.55 ± 0.08* | 97 ± 3 | 3–6 | (Doherty et al., 2005) |
SB705498 | 5.97 + 0.12 | 102 ± 9 | 3 | 5.46 ± 0.16 | 116 ± 12 | 3–6 | (Gunthorpe et al., 2007) |
JNJ17203212 | 6.59 ± 0.09 | 98 ± 6 | 3 | 6.75 ± 0.08 | 98 ± 18 | 3 | (Swanson et al., 2005) |
AMG-9810 | 5.89 ± 0.09 | 88 ± 5 | 3 | 6.81 ± 0.04* | 84 ± 1 | 3 | (Gavva et al., 2010) |
P < 0.01,
P < 0.05.