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. 2013 Jan 24;168(4):1030–1042. doi: 10.1111/j.1476-5381.2012.02232.x

Figure 1.

Figure 1

Compound QO-58 enhances Kv7.2/Kv7.3 channel currents. (A) The structure of compound QO-58 and retigabine. (B) Typical outward currents elicited by step depolarization to −40 mV from a holding potential of −80 mV in the absence and presence of 3 μM QO-58. (C) QO-58 concentration-dependently increased Kv7.2/Kv7.3 channel currents generated at −40 mV. (D) QO-58-induced outward currents were normalized to the maximal effect (Emax) value and fit to a logistic function; EC50 value was 2.3 ± 0.8 μM and the slope factor was 0.6 ± 0.1 (n = 6).