Table 2.
The effects of QO-58 on channels activation and deactivation kinetics of Kv7 subtypes
| Time constants (ms) | |||
|---|---|---|---|
| Control | QO-58 (10 μM) | ||
| Kv7.1 | Activation τ (−40 mV) | 122.5 ± 22.8 | 175 ± 35.9 |
| Deactivation τ (−120 mV) | 31.2 ± 2.3 | 84.2 ± 26.8 | |
| Kv7.2 | Activation τ (−40 mV) | 96.6 ± 12.0 | 137.6 ± 13.4 |
| Deactivation τ (−120 mV) | 15 ± 1.5 | 96.4 ± 12.5 | |
| Kv7.3 | Activation τ (−40 mV) | 166.3 ± 25.7 | 175 ± 18.9 |
| Deactivation τ (−120 mV) | 18.5 ± 3.0 | 29.3 ± 4.2 | |
| Kv7.4 | Activation τ (−40 mV) | 34.4 ± 4.4 | 100.5 ± 3.9 |
| Deactivation τ (−120 mV) | 8.7 ± 0.2 | 316.6 ± 125.8 | |
| Kv7.2/Kv7.3 | Activation τ (−40 mV) | 76.0 ± 2.5 | 179.5 ± 26.4 |
| Deactivation τ (−120 mV) | 28.3 ± 6.8 | 278.5 ± 57.3 | |
| Kv7.3/Kv7.5 | Activation τ (−40 mV) | 83 ± 16.6 | 137 ± 19.6 |
| Deactivation τ (−120 mV) | 32.1 ± 1.8 | 253.2 ± 61.9 | |
All values are mean ± SEM (n = 4–7).