Table 1.
Comparison of the amino-terminal sequence of TcHMGR and LmHMGR with those of different trypanosomatid proteins that undergo mitochondrial import
| Organism | Amino terminal sequencea | Protein |
|---|---|---|
| T. cruzi | MFRRAILLGCSAAK | HMGR |
| L. major (Montalvetti et al., 2000) | MRRSLLLACSAAKGESWASM | HMGR |
| T. brucei (Else et al., 1994) | MFRRCFPIF*NPYD | Lipoamide dehydrogenase |
| C. fasciculata (Xu and Ray, 1993) | MLRRSPTLL*RVSP | p17 |
| T. cruzi (Giambiagi de Marval et al., 1993) | MFRSAARF*AGKE | hsp60 |
| L. tarentolae (Bringaud et al., 1995) | MLRATLAR*EMAP | p51, aldehyde dehydrogenase |
| L. tarentolae (Bringaud et al., 1995) | MRRLSSQLMCTAAAVRF*ASAG | p18 |
| L. major (Searle et al., 1993) | MFARRVCGTAAASAACLVRC*ASDK | mhsp70 |
a
Positively charged residues are in bold. Sequence homologies are underlined.
*
Denotes known cleavage sites.