Table 2.

Linear Mixed-Effects Model-Based Differences in Key Outcomes of Treatment Compared to Baseline by Treatment Group and Difference Between Groups

		Continuous		Cyclic		Difference (Continuous-Cyclic)
	Month	Mean Change (95% CI)	P	Mean Change (95% CI)	P	Mean Change (95% CI)	P
Visual Analog Scale
Degree of dysmenorrhea	1	-72.5 (-81.9,-63.0)	<.001	-45.1 (-54.3,-36.0)	<.001	-27.3 (-40.5,-14.2)	<.001
	3	-73.1 (-84.0,-62.1)	<.001	-55.3 (-66.4,-44.1)	<.001	-17.8 (-33.4,-2.1)	0.03
	6	-74.8 (-86.1,-63.5)	<.001	-58.7 (-70.3,-47.2)	<.001	-16.0 (-32.2,0.1)	0.05
MOOS Menstrual Distress Questionnaire
T-Score Pain Scale (menstrual)	1	-8.0 (-16.7,0.7)	0.07	-4.5 (-12.9,4.0)	0.29	-3.5 (-15.6,8.6)	0.57
	3	-21.0 (-32.4,-9.7)	<.001	-18.5 (-30.0,-6.9)	0.002	-2.6 (-18.8,13.7)	0.76
	6	-23.0 (-35.4,-10.5)	<.001	-18.4 (-31.0,-5.9)	0.004	-4.5 (-22.2,13.2)	0.61
T-Score Pain Scale (premenstrual)	1	-2.5 (-8.0,2.9)	0.35	0.4 (-4.9,5.6)	0.89	-2.9 (-10.5,4.7)	0.45
	3	-6.2 (-14.1,1.6)	0.12	-3.4 (-11.3,4.5)	0.40	-2.8 (-14.0,8.3)	0.61
	6	-6.6 (-15.8,2.7)	0.16	-0.6 (-9.9,8.7)	0.89	-5.9 (-19.1,7.2)	0.37
T-Score Pain Scale (intermenstrual)	1	-6.1 (-12.9,0.8)	0.08	-5.7 (-12.3,1.0)	0.09	-0.4 (-9.9,9.2)	0.93
	3	-13.0 (-22.7,-3.3)	0.009	-10.5 (-20.4,-0.6)	0.04	-2.5 (-16.4,11.4)	0.72
	6	-14.3 (-25.7,-2.9)	0.01	-7.1 (-18.6,4.3)	0.22	-7.2 (-23.4,9.0)	0.38