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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Nat Immunol. 2013 Mar 31;14(5):509–513. doi: 10.1038/ni.2568

Figure 1. Local antigen re-challenge precipitates rapid accumulation of antigen-specific CD8+ T cells within the female reproductive tract (FRT).

Figure 1

Widely disseminated Thy1.1+ memory P14 CD8+ T cells were established after LCMV infection. Immune mice were challenged transcervically (t.c.) with 4×105 p.f.u. VV-gp33 or VV-OVA, 50μg gp33 or SIINFEKL peptide, or left untreated. (a) 48 h later, P14 cells in FRT were enumerated relative to total nucleated cells. (b) Representative images show α-Thy1.1 (red) and DAPI (blue) staining. Scale bars = 100 μm. n = 6, one representative of three experiments. n = 6, pooled from 2 experiments. *, P < 0.05, **, P <0.001, unpaired two-tailed t-test, mean±SEM.