Fig. 3.

Vessels and multinucleate giant cells significantly stained with anti-IL-17C. Immunofluorescence of human IL-17C in the interface membranes surrounding the aseptic loosened implants. The anti-human IL-17C antibody was labeled with CY3 (red). The cell nucleus was counter stained with Dapi (blue). a The “vascular sleeve” structures were also significantly stained (white arrow), suggesting the association of IL-17C with inflammation and vessel responses. b The multinucleate giant cells scattered in the section were also stained (white arrow). These gigantic cells, with several cell nuclei arrayed around the cell membrane to form a “chaplet”, were stained with anti-human IL-17C