Table 1. Demographic and Clinical Characteristics for Patients and Disease-Free Controls.
| Disease-Free Controls Versus MS Patients | MS Eyes with ON Versus Non-ON | |||||
|---|---|---|---|---|---|---|
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| Controls (n = 31; 61 eyes) | MS Patients(n = 122; 239 eyes) | MS ON(n = 87 eyes) | Non-ON(n = 150 eyes) | |||
| Age, yrs, mean (SD) | 40.7 (13.6) | 46.9 (10.7)* | 45.9 (11.5) | 47.5 (10.5) | ||
| Female (%) | 75.4 | 74.5 | 82.8 | 70.0 | ||
| Caucasian (%) | 87.5 | 92.2 | 94.7 | 91.4 | ||
| Age (yrs) at diagnosis of disease, mean (SD) | — | 38.1 (10.3) | 34.9 (9.9) | 39.9 (10.1) | ||
| Duration of disease, yrs, mean (SD) | — | 8.8 (7.8) | 11.0 (8.6) | 7.6 (7.1) | ||
| EDSS, median (range) | — | 1.5 (0.0–7.5) | 1.5 (1.0–7.5) | 1.5 (0.0–3.5) | ||
| High-contrast VA,† mean (SD) | 64.1 (5.1) | 58.9 (7.7) | 57.5 (9.4) | 59.9 (6.4) | ||
| 2.5% LCLA,‡ mean (SD) | 33.6 (7.5) | 26.2 (10.8) | 22.4 (12.4) | 28.3 (9.2) | ||
| 1.25% LCLA,‡ mean (SD) | 24.8 (7.4) | 15.6 (10.4) | 11.4 (10.6) | 18.0 (9.6) | ||
| NEI-VFQ-25 Composite, mean (SD) | 95.9 (3.8) | 88.3 (12.7) | 85.2 (14.2) | 89.6 (11.7) | ||
| 10-item Supplement, mean (SD) | 96.6 (3.3) | 86.7 (12.9) | 82.7 (14.4) | 88.4 (11.7) | ||
EDSS = Expanded Disability Status Scale; LCLA = low contrast letter acuity; MS = multiple sclerosis; NEI-VFQ-25 = 25-item National Eye Institute Visual Function Questionnaire; ON = optic neuritis; SD = standard deviation; VA = visual acuity; 10-item Supplement = 10-item Neuro-Ophthalmic Supplement to the NEI-VFQ-25.
*
Age was significantly greater in patients with MS compared with controls (P = 0.007), 2-sample t test. Age was therefore accounted for in all analyses.
†
Letters seen correctly on Early Treatment Diabetic Retinopathy Study charts at 3.2 m.
‡
Letters seen correctly on Sloan LCLA charts at 2.0 m.