Table 3. Optical Coherence Tomography Changes Corresponding with Clinically Significant Impairment of Vision and Vision-Specific Quality of Life in Multiple Sclerosis (n = 122, 239 eyes).
Macular RNFL Thickness | GCL+IPL Thickness | Macular RNFL+GCL+IPL Thickness | OPL+INL Thickness | ONL+PRL Thickness | Peripapillary RNFL Thickness | |
---|---|---|---|---|---|---|
VA (μm per line [5 letters] of acuity) | 1.3 | 1.3 | 2.7 | −0.6 | −0.3 | 2.2 |
P | <0.001 | 0.001 | <0.001 | 0.002 | 0.25 | <0.001 |
2.5% LCLA (μm per 7 letters of acuity) | 1.9 | 1.9 | 3.8 | −0.7 | −0.8 | 3.3 |
P | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
1.25% LCLA (μm per 7 letters of acuity) | 1.9 | 2.4 | 4.3 | −0.5 | −0.9 | 3.3 |
P | <0.001 | <0.001 | <0.001 | 0.01 | 0.01 | <0.001 |
NEI-VFQ-25 composite score (μm per 5 points) | 0.7 | 0.9 | 1.6 | 0.02 | −0.2 | 1.0 |
P | 0.006 | <0.001 | <0.001 | 0.89 | 0.50 | 0.03 |
10-item supplement composite score (μm per 5 points) | 0.8 | 1.0 | 1.7 | 0.04 | −0.2 | 1.0 |
P | 0.002 | <0.001 | <0.001 | 0.78 | 0.44 | 0.05 |
Peripapillary RNFL loss (μm per 10am RNFL) | 3.4 | 4.2 | 7.6 | −0.26 | −0.12 | — |
P | <0.001 | <0.001 | <0.001 | 0.31 | 0.69 |
GCL = ganglion cell layer; INL = inner nuclear layer; IPL = inner plexiform layer; LCLA = low contrast letter acuity; NEI-VFQ-25 = National Eye Institute Visual Function Questionnaire; ONL = outer nuclear layer; OPL = outer plexiform layer; PRL = photoreceptor layer; RNFL = retinal nerve fiber layer; VA = visual acuity.
Letters seen correctly on Early Treatment Diabetic Retinopathy Study charts at 3.2 m.
Letters seen correctly on Sloan LCLA charts at 2.0 m.
P-values reflect generalized estimating equation models accounting for age and within-patient intereye correlations.