Table 2.
Reading Center Team grading agreement for quantitative OCT evaluation
| Variable | Statistic | Reading Center Team A |
Reading Center Team B |
Paired Difference | P-Value* |
|---|---|---|---|---|---|
| RPE Elevation Height - maximum vertical dimension on any scan (micrometers) | N | 226* | |||
| Mean (SD) | 165 (159) | 177 (175) | −8 (42) | ||
| Min,Median,Max | 22,121,1210 | 22,116,1210 | −220,0,110 | 0.02 | |
| ICC (95% CI) | 0.97 (0.96 to 0.97) | ||||
| RPE Elevation Width - maximum horizontal dimension on any scan (micrometers) | N | 210** | |||
| Mean (SD) | 771 (525) | 808 (535) | −62 (313) | ||
| Min,Median,Max | 110,616,2530 | 88,665.5,2607 | −1320,−11,1760 | 0.001 | |
| ICC (95% CI) | 0.81 (0.76 to 0.85) | ||||
| Mean Retinal Thickness at Foveal Center Point (micrometers) | N | 270 | |||
| Mean (SD) | 174 (82) | 177 (82) | −3 (30) | ||
| Min,Median,Max | 18,161,557 | 11,161,559 | −223,0,172 | 0.43 | |
| ICC (95% CI) | 0.93 (0.92 to 0.95) | ||||
| Mean Subretinal Fluid Thickness at Foveal Center Point (micrometers) | N | 270 | |||
| Mean (SD) | 10 (33) | 9 (30) | 0.6 (14) | ||
| Min,Median,Max | 0,0,229 | 0,0,255 | −37,0,167 | 0.33 | |
| ICC (95% CI) | 0.90 (0.88 to 0.92) | ||||
| CNV-PED Complex Thickness at Foveal Center Point (micrometers) | N | 270 | |||
| Mean (SD) | 144 (160) | 145 (159) | −2 (30) | ||
| Min,Median,Max | 22,68,1045 | 22,78,1027 | −231,0,145 | 0.058 | |
| ICC (95% CI) | 0.98 (0.98 to 0.99) | ||||
| Mean Total Thickness at Foveal Center Point (micrometers) | N | 270 | |||
| Mean (SD) | 327 (181) | 331 (182) | −4 (26) | ||
| Min,Median,Max | 114,260,1136 | 112, 264,1205 | −84,0,99 | 0.026 | |
| ICC (95% CI) | 0.99 (0.99 to 0.99) | ||||
OCT = optical coherence tomography. RPE = retinal pigment epithelium. CNV-PED complex = Mean RPE + RPE Elevation + Subretinal Hyper Reflective Material thickness. ICC = intraclass correlation. SD = standard deviation. CI = confidence interval. Thickness refers to measurement of vertical dimension at the foveal center point unless otherwise specified. The second grading teams performed repeat evaluation of images at least 5 weeks after the images were initially graded by the first grading team. A morphological feature was not interpretable for grading if any one of the following conditions existed: inadequate positioning, poor saturation, absent scan, or portion of feature extends off radial line scan.
RPE Elevation not present on every scan for measurement.
RPE Elevation width extended off screen preventing measurement in 16 scans.