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Effects of BAPN treatment to inhibit LOX activity. (A) SHG images showed no apparent differences in collagen microstructure with BAPN treatment compared with a saline control. (Scale bar, 10 μm.) (B) BAPN treatment also had no effect on Hyp content, representative of collagen content, during development (P ≥ 0.51; n = 3). (C) BAPN treatment significantly reduced tendon elastic modulus measured with a nanoscale tip by 38% at HH 40 (*P < 0.05) and by 68% at HH 43 (**P < 0.001; n = 5).
