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. 2013 Apr 1;110(16):E1490–E1499. doi: 10.1073/pnas.1219992110

Fig. 6.

Fig. 6.

NOTCH-PBX1–driven transcriptional program predicts patient outcomes. (A) Kaplan–Meier analysis for recurrent events using the NOTCH-PBX1 gene signature consisting of PBX1 and the 24 genes whose expression is affected by MRK003 and siPBX1 in LTED cells that are found in at least 10% of all breast cancer poor-outcome expression signatures. Both the 5 and +15 y analysis is presented. (B) Kaplan–Meier analysis for metastatic events for 5 or +15 y analysis is presented as in A. (C) Schematic representation of changes in pathway addiction based on epigenetic reprogramming between ET-responsive and -resistant breast cancer cells.