Figure 1.

(A) Complex and multiple role of the cytoskeleton in mitochondrial regulations under normal and pathological conditions. SR, sarcoplasmic reticulum. (B) Possible interactions of porin (VDAC) of the mitochondrial outer membrane (MOM). IFs, intermediate filaments; IMM, the inner mitochondrial membrane; IMS, inter-membrane space; Mito CK, mitochondrial creatine kinase. Tubulin controls VDAC permeability for ADP and ATP. LP is a still unknown cytoskeletal linker protein, which may also interact with VDAC and tubulin to regulate permeability of the MOM.