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The evolving landscape of established type 2 diabetes-associated genetic loci. Effect estimates and list of loci are adapted from reference 21. Variants in CCND2 and GIPR (not shown in Fig.) have sex-heterogeneous effects, with the former having a larger effect in males and the latter in females (21). *This locus was initially associated with type 2 diabetes by Renström et al. (67).
