Appendix Table 1.

Changes to the drug interaction table

Drug-drug Interactions Changed from Severe to Moderate
•amiodarone – bisacodyl •potassium sparing diuretic - potassium salt •allopurinol – mercaptopurine •anticoagulant – alteplase •aminoglycosides – neuromuscular blockers •amikacin – neomycin •amikacin – gentamicin •furosemide – amikacin
•aminoglycosides – bacitracin •indomethacin – aspirin •ibuprofen – aspirin •ampicillin – methotrexate •methotrexate – amoxicillin •amiodarone – senna •vitamin D or vitamin D analogs – multivitamin preparations
•aminoglycosides – neuromuscular blockers •metolazone – linezolid •zonisamide – aripiprazole
•drugs with anticholinergic activity – potassium chloride
•bupropion – triamcinolone
Downgrade severity of interaction between TNF-blockers and immunosuppressive/myelosupressive agents. Affects 135 drug interaction pairs.
•spironolactone – potassium chloride •propranolol – albuterol •methotrexate – etanercept •valproic acid – lamotrigine •ibuprofen – ketorolac •lamotrigine – divalproex •gentamicin – furosemide •methotrexate – sulfamethoxazole-trimethoprim