Table 3.
Univariate and multivariate analysis of the prognostic factors for overall survival
| Prognostic factors | Univariate analysis | Multivariate analysis | ||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Gender | ||||||
| Female | 1 | |||||
| Male | 1.011 | 0.490-2.085 | 0.977 | NA | NA | NA |
| Age | ||||||
| < 59 | 1 | |||||
| ≥ 59 | 1.579 | 0.750-3.326 | 0.229 | NA | NA | NA |
| T-stage | ||||||
| T1-2 | 1 | |||||
| T3-4 | 1.118 | 0.493-2.534 | 0.789 | NA | NA | NA |
| N-stage | ||||||
| N0 | 1 | |||||
| N1-2 | 2.172 | 1.056-4.468 | 0.035 | NS | NS | NS |
| M-stage | ||||||
| M0 | 1 | 1 | ||||
| M1 | 6.324 | 2.659-15.041 | < 0.001 | 7.694 | 2.927-20.224 | < 0.001 |
| Tumor differentiation | ||||||
| Moderate/good | 1 | |||||
| Poor | 1.290 | 0.491-3.384 | 0.229 | NA | NA | NA |
| Vascular invasion | ||||||
| No | 1 | |||||
| Yes | 3.398 | 1.601-7.211 | 0.001 | NS | NS | NS |
| Tumor location | ||||||
| Rectum | 1 | |||||
| Colon | 1.188 | 0.517-2.729 | 0.685 | NA | NA | NA |
| CEA level (ng/mL) | ||||||
| ≤ 5 | 1 | |||||
| > 5 | 3.173 | 1.475-6.827 | 0.003 | NS | NS | NS |
| Twist2 expression | ||||||
| Negative | 1 | 1 | ||||
| Positive | 4.964 | 1.181-20.863 | 0.029 | 5.744 | 1.347-24.298 | 0.018 |
Multivariate analysis included adjustment for N-stage, M-stage, vascular invasion, serum carcinoembryonic antigen level and Twist2 expression. T: Tumor; N: Node; M: Metastasis; HR: Hazard ratio; NA: Not available; NS: Not significant.