Table 4.
Univariate and multivariate analysis of the prognostic factors for disease-free survival
| Prognostic factors | Univariate analysis | Multivariate analysis | ||||
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Gender | ||||||
| Female | 1 | |||||
| Male | 1.001 | 0.587-1.706 | 0.998 | NA | NA | NA |
| Age | ||||||
| < 59 | 1 | |||||
| ≥ 59 | 1.060 | 0.621-1.809 | 0.831 | NA | NA | NA |
| T-stage | ||||||
| T1-2 | 1 | |||||
| T3-4 | 1.258 | 0.833-1.899 | 0.276 | NA | NA | NA |
| N-stage | ||||||
| N0 | 1 | 1 | ||||
| N1-2 | 2.511 | 1.468-4.295 | 0.001 | 2.149 | 1.226-3.767 | 0.008 |
| M-stage | ||||||
| M0 | 1 | 1 | ||||
| M1 | 11.737 | 5.442-25.313 | < 0.001 | 10.907 | 4.937-24.096 | < 0.001 |
| Tumor differentiation | ||||||
| Moderate/good | 1 | |||||
| Poor | 1.140 | 0.537-2.418 | 0.733 | NA | NA | NA |
| Vascular invasion | ||||||
| No | 1 | |||||
| Yes | 3.246 | 1.874-5.625 | < 0.001 | NS | NS | NS |
| Tumor location | ||||||
| Rectum | 1 | |||||
| Colon | 1.557 | 0.810-2.992 | 0.184 | NA | NA | NA |
| CEA level (ng/mL) | ||||||
| ≤ 5 | 1 | |||||
| > 5 | 2.958 | 1.692-5.172 | < 0.001 | NS | NS | NS |
| Twist2 expression | ||||||
| Negative | 1 | 1 | ||||
| Positive | 2.632 | 1.184-5.809 | 0.017 | 3.264 | 1.455-7.375 | 0.004 |
Multivariate analysis included adjustment for N-stage, M-stage, vascular invasion, serum carcinoembryonic antigen level and Twist2 expression. T: Tumor; N: Node; M: Metastasis; HR: Hazard ratio; NA: Not available; NS: Not significant.