. Author manuscript; available in PMC: 2013 Apr 22.

Published in final edited form as: Clin Immunol. 2012 Jan 14;142(3):390–398. doi: 10.1016/j.clim.2012.01.002

Table 2.

Associations between IgM antibody levels and disease activity and damage indices.

IgM anti-	SLEDAI^a		Phys. est.^b		SLICC
(≥ median)	Odds ratio (95% CI)	p-Values	Odds ratio (95% CI)	p-Values	Odds ratio (95% CI)	p-Values
PC	0.24 (0.15, 0.55)	0.0007^*	0.47 (0.23, 0.99)	0.046^*	0.37 (0.17, 0.82)	0.014^*
MDA	1.00 (0.47, 2.1)	1.00	1.22 (0.60, 2.50)	0.58	0.51 (0.24, 1.10)	0.085
β2-GPI	1.00 (0.47, 2.1)	1.00	0.55 (0.26, 1.13)	0.10	0.44 (0.20, 0.95)	0.036^*
CL	0.64 (0.24, 1.68)	0.36	0.87 (0.38, 1.98)	0.74	0.84 (0.35, 2.04)	0.70
dsDNA	1.30 (0.50, 3.39)	0.59	0.73 (0.32, 1.66)	0.45	1.26 (0.52, 3.05)	0.61

Odds ratios and p-values presented from Fisher's exact test comparing autoantibody levels dichotomized on median level of IgM antibody (anti-PC = 18.6; anti-MDA=13.6; anti-β2-GPI=3.8; anti-CL=7.9; anti-dsDNA=227) with SLEDAI dichotomized on 4, physician's estimate of disease dichotomized on median of 0.5, or SLICC dichotomized on median of 3.

Some samples were insufficient for all tests. IgM anti-CL and anti-dsDNA: n=95; all other: n=120.

SLEDAI includes IgG anti-dsDNA positive.

Phys. est., physician's estimate of lupus activity index, 1–3.

Statistically significant.