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. 2013 Feb 5;53(3):613–622. doi: 10.1021/ci3005379

Table 4. Reaction Modules Corresponding to Enzyme Gene Clusters.

RC module overall reaction KO module gene cluster examplea
RM001 oxaloacetate → 2-oxoglutarate M00010 (pfu) PF0203 PF0201 PF0202
2-oxoisovalerate → 2-oxoisocaproate M00432 (pfu) PF0937 PF0938+PF0939 PF0940
pyruvate → 2-oxobutanoate M00535 (bth) BT_1858 BT_1860+BT_1859 BT_1857
RM002 2-aminoadipate → lysine M00028 (bsu) BSU11200 BSU11210+BSU11190 BSU11220
glutamate → ornithine M00031 (ttr) Tter_0315+Tter_0316 Tter_0320 Tter_0319 Tter_0321 Tter_0317
a

KEGG organism codes are shown in parentheses: pfu (T00075), Pyrococcus furiosus DSM 3638; bth (T00122), Bacteroides thetaiotaomicrometer VPI-5482; bsu (T00010), Bacillus subtilis 168; ttr (T01134), Thermobaculum terrenum ATCC BAA-798.