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. 2013 Feb 22;41(8):4573–4586. doi: 10.1093/nar/gkt113

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Models for stop codon recognition by eRF1. (Step 1) Binding of eRF1 to the A site of the ribosome. Recognition of the first and second nucleotides of stop codon (UA or UG). Second A and G are decoded at different sites of eRF1. (Step 2) Rotation of eRF1 within the ribosome and decoding of the second and third nucleotides of stop codon (AG, AA or GA). Two possible modes of stop codon interactions. (I) The different amino acid residues of eRF1 directly decode the third A or G, and the ribosome recognizes the second A/G or A according to the third nucleotide. (II) eRF1 decodes the second nucleotide (A/G or A), and the ribosome interacts with the third A or G, respectively. The ribosome is shown in beige, eRF1 is in green, the first, second and third nucleotides of stop codon are in blue, red and yellow, respectively.