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. 2013 Mar 6;41(8):4671–4685. doi: 10.1093/nar/gkt153

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Heat stress caused nuclear accumulation of tRNA(iMet). Nuclear accumulation of tRNA(iMet) was monitored by FISH in HeLa cells at 37°C (A) and 43°C (B) for the time indicated. (C) Ratio of cytoplasmic to nuclear tRNA(iMet) at 37°C (black) and at 43°C (red) is shown. Quantification of fluorescence was performed in 40 cells per hour by using the LAS program (Leica) and the results were averaged. Data represent the mean±SD (n = 40). (D) Superposition of degradation and accumulation of tRNA(iMet). The circles show the degradation of tRNA(iMet). The squares show accumulation of tRNA(iMet) from the cytoplasm to the nucleus.