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Orchestra of contributing factors to the development of diabetic cardiomyopathy concerning fatty acid and glucose metabolism, (adapted from Boudina and Abel [60]). ACC, acetyl-CoA carboxylase; ACoA, acetyl-CoA; CE, cardiac efficiency; CPT1, carnitine-palmitoyltransferase 1; FA, fatty acid; MCD, malonyl-CoA decarboxylase; MCoA, malonyl-CoA; PDH, pyruvate dehydrogenase; PDK4, pyruvate dehydrogenase kinase 4; TG, triglycerides.
