Table 1.

Relationship of severe hypoglycemia to mortality outcome in recent clinical trials assessing intensive glycemic control

Clinical trial	Incidence of severe hypoglycemia (%)	Mortality during study (% per year)	HR
ACCORD (10)
Standard glycemic control	5.0
No severe hypoglycemia		1.0
Severe hypoglycemia (≥1 episode)		4.9
Intensive glycemic control	15.9
No severe hypoglycemia		1.3
Severe hypoglycemia (≥1 episode)		2.8
VADT (11,12)
Moderate glycemic control	9.7
Intensive glycemic control	21.1
HR if severe hypoglycemia
All-cause mortality			6.37
Cardiovascular mortality			3.73
NICE-SUGAR study (14)
Intensive glycemic control	6.8
Ordinary glycemic control	0.5
HR for mortality in intensive control as compared with ordinary glycemic control			1.14