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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: J Med Chem. 2013 Mar 28;56(7):3024–3032. doi: 10.1021/jm4000984

Figure 5.

Figure 5

Crystallographic binding conformations of 6 (PDB ID 4IMU) with rat nNOS. The Fo – Fc omit density map for inhibitor is shown at 2.5 σ contour level. Although binding of 6 does not disturb the H4B site it still creates a new Zn binding site. Arg596 is also salt bridged with Glu592.