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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: J Med Chem. 2013 Mar 28;56(7):3024–3032. doi: 10.1021/jm4000984

Table 1.

Inhibition of NOS isozymes by synthetic inhibitorsa

No. Ki (µM) Selectivity
nNOS eNOS iNOS n/e n/i
2 2.10 63.2 36.7 30 17
3 5.75 97.4 138.0 17 24
4 0.54 12.1 32.5 22 60
5 0.11 33.4 21.9 303 199
6 0.053 11.7 6.31 221 119
7 0.056 26.4 13.4 472 239
a

The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS, and marine iNOS using known literature methods. (Hevel, J.M.; Marletta, M.A. Nitric-oxide synthase assays. Method Enzymol. 1994, 233, 250–258)