Table 2.

Effect of NaHS on RPMCs and ripples in the presence of lidocaine

RPMCs (proximal)	Control	Lidocaine	Serosal NaHS
		100 μM	0.3 mM	1 mM
Frequency (cpm)	1.3 ± 0.3	0.5 ± 0.1a	0.0 ± 0.0b	0.0 ± 0.0b
Amplitude (mm)	2.0 ± 0.2	2.3 ± 0.4	0.0 ± 0.0b	0.0 ± 0.0b
Duration (s)	32.2 ± 3.3	21.7 ± 2.0	0.0 ± 0.0c	0.0 ± 0.0c
Propagation (cm min−1)	4.6 ± 0.2	5.8 ± 0.3a	0.0 ± 0.0c	0.0 ± 0.0c

Ripples	Control	Lidocaine	Serosal NaHS
		100 μM	0.3 mM	1 mM
Frequency (cpm)	11.1 ± 0.9	13.4 ± 0.4	13.4 ± 0.9	11.1 ± 1.1a
Amplitude (mm)	0.6 ± 0.1	0.5 ± 0.1	0.8 ± 0.1	1.0 ± 0.2a
Duration (s)	4.7 ± 0.2	3.8 ± 0.2	4.4 ± 0.4	5.3 ± 0.7a
Presence (cm)*	3.5 ± 0.2	4.4 ± 0.6	5.9 ± 0.5	6.1 ± 0.9
Propagation (cm min−1)
Aboral (anterograde)	6.3 ± 0.4	6.6 ± 1.0	5.6 ± 0.4	6.3 ± 0.4
Oral (retrograde)	6.0 ± 0.1	6.3 ± 0.2	6.3 ± 0.6	6.6 ± 0.9

Values are means ± SEM. n = 4. Note that lidocaine (100 μM) abolished RPMCs in the mid colon, therefore these data were not included in this table.

^aP < 0.05;

^bP < 0.01;

^cP < 0.001, significant difference from control or lidocaine (100 μM) respectively; paired Student's t-test (lidocaine vs. control) and one-way anova, followed by Bonferroni's multiple comparison test (NaHS vs. lidocaine).

^*Distance in which ripples were observed from the proximal edge of the colon.