Figure 1.

AMG 181 binds to α₄β₇ receptors on human CD4+CD45RA-memory T cells as well as on cynomolgus monkey CD4+CD28+CD95+ central memory T cells (A), thus blocks binding of MAdCAM-1 to α₄β₇ receptors (B). Symbols represent observations (mean ± SEM), while lines represent the four-parameter Hill equation fitted curves. For the binding study on monkey T cells (n = 2), range is plotted instead of SEM (A). For the blocking of binding study on monkey T cells (2 sets of experiments at different titrated AMG 181 concentrations), individual observations are plotted (B).