Table 1.
Effects of U0126 on the plasma lipid levels in db/db mice
| Group | Total cholesterol (mg·dL−1) | Triglyceride (mg·dL−1) | HDL cholesterol (mg·dL−1) | LDL cholesterol (mg·dL−1)a |
|---|---|---|---|---|
| WT (Lean) | 136.6 ± 8.9 | 70.0 ± 4.5 | 62.0 ± 0.8 | 60.6 ± 9.2 |
| db | 209.3 ± 7.3 | 147.5 ± 10.3 | 54.0 ± 7.0 | 129.3 ± 11.1 |
| db+U0126 | 210.9 ± 10.0 | 109.1 ± 6.7* | 75.9 ± 1.8* | 113.1 ± 9.7 |
| db+Rosi | 307.4 ± 29.1* | 83.0 ± 13.6** | 79.6 ± 1.8* | 181.6 ± 19.0* |
Each value is mean ± SE for six mice. *P < 0.05, **P < 0.01 compared to db control.
a
Total cholesterol – HDL cholesterol – Triglyceride/5.