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IL-33/ST2 mediates carrageenin-induced paw inflammation. WT ( ST2+/+) and ST2−/− mice received i.pl. injection of carrageenin (100 μg·per paw) or saline. Mechanical hyperalgesia (panel A) and oedema (panel B) were determined at indicated time points followed by myeloperoxidase assay at 5 h (panel C) in paw skin samples. n = 5, representative of two separate experiments. *P < 0.05 compared with the saline group and #P < 0.05 compared with the carrageenin group.
