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. 2013 Apr 12;169(1):90–101. doi: 10.1111/bph.12110

Figure 3.

Figure 3

IL-33 induces hyperalgesia, oedema and neutrophil migration in a ST2-dependent manner in normal mice. IL-33 (30–300 ng) or saline (25 μL) was injected i.pl. in WT (ST2+/+) mice. Mechanical hyperalgesia (panel A) and oedema (panel B) were determined at indicated time points followed by myeloperoxidase activity determination at 5 h (panel C) in paw skin samples. IL-33 (100 ng) or saline was injected i.pl. in WT and ST2−/− mice. Mechanical hyperalgesia (panel D) and oedema (panel E) were determined at indicated time points followed by myeloperoxidase activity determination at 5 h (panel F). n = 6, representative of two separate experiments. *P < 0.05 compared with the saline group and #P < 0.05 compared with the lower dose of IL-33 or IL-33 injection in ST2+/+ mice.